Effects of reduced glomerular filtration rate on responsiveness to chlorothiazide and mercurial diuretics.
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چکیده
منابع مشابه
Relationship between diuretic and antihypertensive effects of chlorothiazide and mercurial diuretics.
ORAL chlorothiazide has been shown by a number of workers to be effective as an antihypertensive as well as a diuretic agent.1-'5 Parenteral mercurial diuretics likewise have been found to exert a hypotensive action in hypertensive subjects with or without complicating heart failure.12' 13, 16 Although the mode of action of these diuretic agents on the blood pressure has not been clearly determ...
متن کاملMechanisms Contributing to Unresponsiveness to Mercurial
The ultimate failure of edematous cardiac patients to respond to mercurial diuretics is well established. Although the older literature ascribed this to renal tubular accommodation to mercury, some patients have received mercurials for many years without manifesting such acquired tubular resistance. More recently, because of the potentiation of mercurial diuresis in previously unresponsive pati...
متن کاملMechanism of the antihypertensive effects of diuretics. Possible role of salt in hypertension.
The mechanism of the antihypertensive effect of chlorothiazide does not difler from that of such potent salt-depleting therapeutic agents as the mercurial diuretics and tlw rice diet. The extracellular fluid and plasma volumes are reduced and, as 44 result, right hecrrt filling pressure, cardiac output, and blood pressure (if abnormally elevated by some pressor stimu1u.y) fall. Becal4se of the ...
متن کاملModification by ascorbic acid and British antilewistte of the effect of mercuhydrin on renal tubular function in man.
Alteration of renal hemodynamics and tubular function following administration of organic mercurial compounds has been investigated by several workers (1, 2). These compounds have no effect on the glomerular filtration rate or effective renal plasma flow. The maximal capacity of the tubules to excrete para-aminohippurate in man (TmpH) is depressed by the administration of mercurial diuretics. B...
متن کاملEffects of increased sodium delivery on distal tubular sodium reabsorption with and without volume expansion in man.
The separate effects of volume expansion and of increased delivery of sodium on sodium reabsorption in the diluting segment of the distal nephron were studied in man. In six normal subjects during a sustained water diuresis, sodium delivery to the distal nephron was increased without volume expansion by the administration of acetazolamide. In these subjects, free water clearance rose linearly a...
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ورودعنوان ژورنال:
- Circulation
دوره 23 شماره
صفحات -
تاریخ انتشار 1961